Important Safety Info for GLP-1s
See Important Safety Information, including Boxed Warning, about:
Important Safety Information for Wegovy® (semaglutide) injection
⚠️ Warning: Risk of Thyroid C-Cell Tumors
In studies with mice and rats, semaglutide (the active ingredient in Wegovy and Ozempic) caused thyroid tumors, including thyroid cancer. It is not known if Wegovy will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. Tell your provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer.
Do not use Wegovy if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
What is the FDA-approved use?
Wegovy is used along with a reduced-calorie diet and increased physical activity for chronic weight management in adults with obesity or with overweight plus a weight-related condition. It is also used to reduce the risk of major adverse cardiovascular events in adults with known cardiovascular disease and with either obesity or overweight.
Most serious side effects to monitor:
- •Thyroid C-Cell Tumors
- •Inflammation of Pancreas (Acute Pancreatitis)
- •Acute Gallbladder Disease
- •Low Blood Sugar (Hypoglycemia)
- •Acute Kidney Injury
- •Severe Gastrointestinal Adverse Reactions
- •Serious Allergic Reactions
- •Diabetic Retinopathy Complications
- •Increase in Heart Rate
- •Pulmonary Aspiration During General Anesthesia
Most common side effects:
This information is not comprehensive. Please see the full Prescribing Information for complete safety information.
Report negative side effects to FDA MedWatch at 1-800-FDA-1088 or www.fda.gov/medwatch
Important Safety Information for Zepbound® (tirzepatide) injection
⚠️ Warning: Risk of Thyroid C-Cell Tumors
In rats, Zepbound caused thyroid tumors, including thyroid cancer. It is not known if Zepbound will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. Tell your provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer.
Do not use Zepbound if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
What is the FDA-approved use?
Zepbound is used along with a reduced-calorie diet and increased physical activity for chronic weight management in adults with obesity or with overweight plus a weight-related condition.
Most serious side effects to monitor:
- •Thyroid C-Cell Tumors
- •Severe Gastrointestinal Disease
- •Acute Kidney Injury
- •Acute Gallbladder Disease
- •Inflammation of Pancreas (Acute Pancreatitis)
- •Allergic Reactions
- •Low Blood Sugar (Hypoglycemia)
- •Diabetic Retinopathy Complications
- •Pulmonary Aspiration During General Anesthesia
Most common side effects:
This information is not comprehensive. Please see the full Prescribing Information for complete safety information.
Report negative side effects to FDA MedWatch at 1-800-FDA-1088 or www.fda.gov/medwatch
Important Safety Information for Ozempic® (semaglutide) injection
⚠️ Warning: Risk of Thyroid C-Cell Tumors
In studies with mice and rats, semaglutide (the active ingredient in Ozempic and Wegovy) caused thyroid tumors, including thyroid cancer. It is not known if Ozempic will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. Tell your provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer.
Do not use Ozempic if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
What is the FDA-approved use?
Ozempic is a GLP-1 receptor agonist used with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus, and to reduce the risk of major adverse cardiovascular events in patients with type 2 diabetes and established cardiovascular disease.
Most serious side effects to monitor:
- •Thyroid C-Cell Tumors
- •Inflammation of Pancreas (Acute Pancreatitis)
- •Diabetic Retinopathy Complications
- •Low Blood Sugar (Hypoglycemia)
- •Acute Kidney Injury
- •Serious Allergic Reactions
- •Acute Gallbladder Disease
- •Increase in Heart Rate
Most common side effects:
This information is not comprehensive. Please see the full Prescribing Information for complete safety information.
Report negative side effects to FDA MedWatch at 1-800-FDA-1088 or www.fda.gov/medwatch
Important Safety Information for Foundayo™ (orforglipron) tablet
⚠️ Warning: Risk of Thyroid C-Cell Tumors
In rats and mice, certain GLP-1 medications caused thyroid C-cell tumors. Foundayo did not produce these tumors in rats and mice. However, it is unknown whether Foundayo causes these tumors in people. Tell your provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer.
Do not use Foundayo if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have a condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
What is the FDA-approved use?
Foundayo is used along with a reduced-calorie diet and increased physical activity to reduce and maintain weight in adults with obesity or with overweight plus a weight-related condition.
Most serious side effects to monitor:
- •Thyroid C-Cell Tumors
- •Inflammation of Pancreas (Acute Pancreatitis)
- •Severe Gastrointestinal Disease
- •Acute Kidney Injury
- •Low Blood Sugar (Hypoglycemia)
- •Allergic Reactions
- •Diabetic Retinopathy Complications
- •Acute Gallbladder Disease
- •Pulmonary Aspiration During General Anesthesia
Most common side effects:
This information is not comprehensive. Please see the full Prescribing Information for complete safety information.
Report negative side effects to FDA MedWatch at 1-800-FDA-1088 or www.fda.gov/medwatch
Disclaimer: The safety information provided on this page is sourced from publicly available FDA-approved prescribing information and drug labels. Youth & Soul is not a healthcare provider or pharmacy. Always consult with your licensed healthcare provider before starting any medication. This page is for informational purposes only.