Youth and Soul Top Picks for 2026: 1) Tirzepatide/Zepbound - 22.5% weight loss, Editors Choice. 2) Semaglutide/Wegovy - 15-17% loss, Best Value at $125/mo through Youth and Soul. 3) Liraglutide/Saxenda - 8% loss, good starter option. All require BMI 30+ or 27+ with comorbidities. Start now | Weight loss programs. Source: Nature Medicine