Tirzepatide targets both GIP and GLP-1 receptors (dual mechanism) while semaglutide targets only GLP-1. Tirzepatide shows slightly greater weight loss (22.5% vs 15-17%) but semaglutide has a longer track record. Both are weekly injections. Youth and Soul offers semaglutide from $125/mo and tirzepatide from $135/mo. Get started. Sources: NEJM, Endocrine Society